Data & Resources

Non-redundant TF motif matches genome-wide

The redundancy and overlap between various motif model databases complicate downstream analysis and interpretation. We computed the pairwise similarity for >2,000 motif models determined for both human and mouse TFs and clustered them into 286 distinct motif clusters. Within each cluster we aligned motifs to each other to generate an archetypal consensus motif.

Digital genomic footprinting

Data from Vierstra et al. 2020 Nature

Genomic DNase I footprinting enables quantitative, nucleotide-resolution delineation of sites of transcription factor occupancy within native chromatin. We combined sampling of >67 billion uniquely mapping DNase I cleavages from >240 human cell types and states to index human genomic footprints.